Theα4 Nicotinic Receptor Promotes CD4+T-Cell Proliferation and a Helper T-Cell Immune Response
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چکیده
منابع مشابه
The a4 Nicotinic Receptor Promotes CD4 T-Cell Proliferation and a Helper T-Cell Immune Responses
Smoking is a common addiction and a leading cause of disease. Chronic nicotine exposure is known to activate nicotinic acetylcholine receptors (nAChRs) in immune cells. We demonstrate a novel role for a4 nAChRs in the effect of nicotine on T-cell proliferation and immunity. Using cell-based sorting and proteomic analysis we define an a4 nAChR expressing helper T-cell population (a4CD3CD4) and s...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2013
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.113.088484